| 5 Nov | Louisville 87 | at | Miami FL 74 | |||
| 10 Nov | Youngstown St 55 | at | Louisville 78 | vs HL | ||
| 13 Nov | Indiana St 62 | at | Louisville 91 | vs MVC | ||
| 17 Nov | NC Central 58 | at | Louisville 87 | vs MEAC | ||
| 20 Nov | SC Upstate 50 | at | Louisville 76 | vs BSo | ||
| 24 Nov | Akron 76 | at | Louisville 82 | vs MAC | ||
| 29 Nov | Louisville 71 | vs | WKU 54 | Nashville, TN | vs CUSA | |
| 3 Dec | Michigan 43 | at | Louisville 58 | vs B10 | ||
| 6 Dec | Pittsburgh 46 | at | Louisville 64 | |||
| 10 Dec | Texas Tech 70 | vs | Louisville 57 | New York, NY | vs B12 | |
| 14 Dec | E Kentucky 67 | at | Louisville 99 | vs OVC | ||
| 18 Dec | Miami OH 46 | at | Louisville 70 | vs MAC | ||
| 28 Dec | Louisville 70 | at | Kentucky 78 | OT | at SEC | |
| 4 Jan | Florida St 78 | at | Louisville 65 | |||
| 7 Jan | Miami FL 58 | at | Louisville 74 | |||
| 11 Jan | Louisville 67 | at | Notre Dame 64 | |||
| 14 Jan | Louisville 73 | at | Pittsburgh 68 | OT | ||
| 18 Jan | Louisville | at | Duke | |||
| 22 Jan | Georgia Tech | at | Louisville | |||
| 25 Jan | Clemson | at | Louisville | |||
| 29 Jan | Louisville | at | Boston College | |||
| 1 Feb | Louisville | at | NC State | |||
| 5 Feb | Wake Forest | at | Louisville | |||
| 8 Feb | Virginia | at | Louisville | |||
| 12 Feb | Louisville | at | Georgia Tech | |||
| 15 Feb | Louisville | at | Clemson | |||
| 19 Feb | Syracuse | at | Louisville | |||
| 22 Feb | North Carolina | at | Louisville | |||
| 24 Feb | Louisville | at | Florida St | |||
| 1 Mar | Virginia Tech | at | Louisville | |||
| 7 Mar | Louisville | at | Virginia |
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